College or School: 
Boonshoft School of Medicine
Degree: 
Master of Science
Program Type: 
Master
Level: 
Graduate
Department: 
Pharmacology and Toxicology
Campus: 
Dayton
Program Description: 

The program leading to the Master of Science degree in the Department of Pharmacology and Toxicology will prepare students for careers in industry, government, education, and research organizations or for further professional training. It is offered in close cooperation with the U.S. Air Force and Navy Toxicology Laboratories located at Wright-Patterson Air Force Base.

This program differs from other undergraduate major or master’s-level programs currently offered at Wright State University, both conceptually and with respect to employment and career options. It provides a comprehensive introduction to the broad range of theoretical concepts that comprise these disciplines, providing both historical context and state-of-the-art technical approaches to solving pharmacological and toxicological problems. This goal of providing students with a career-oriented yet theoretically based education will be accomplished within the core curriculum through the combination of text and literature-based lectures, complemented by laboratory instruction and journal club type seminars, and culminating with a thesis research project.

Admissions Requirements: 

Applicants must fulfill the requirements for admission established by the Graduate School. A baccalaureate degree in physical, chemical, or life sciences with undergraduate level courses in biochemistry, molecular biology, molecular genetics, and cell biology is generally required. Preference is given to applicants with a GPA of 3.0 or greater. A personal goals statement and three letters of recommendation are required. For international students, a TOEFL minimum score of 213(CBT) or 79/120(IBT) or a band 6 through the International English Language Testing System (IELTS).

Program Requirements: 

To qualify for the Master of Science degree, students must satisfy the requirements of the School of Graduate Studies, as well as the program requirements. During the first year thesis option students will be required to enroll in 12-15 hours of didactic course work supplemented by laboratory rotations and research activities. During the second year, students will focus on developing a research-based thesis culminating with an oral thesis defense.    Students preferring the non-thesis option enroll in 21 hours of core course work and an additional 9 hours of elective courses.  The non-thesis program requires a scientific review and a final oral exam. Students from both options are required to attend department seminars.

II. Departmental Requirements Hours
Thesis Option: 31
PTX 7500:Research Techniques 3
PTX 7600:Biostatistics 3
PTX 7200:Principles of Biokinetics/Biodynamics 3
PTX 7300:Cellular Pharm&Tox 3
PTX 7120:Seminar/Journal Club 3
PHA 9000:Into to Pharmacology Research 3
PHA 9100:Into to Pharmacology Research 10
Electives (6xx level or higher) 3
   
Non Thesis option: 30
PTX 7400:Laboratory Management 3
PTX 7600:Biostatistics 3
PTX 7200:Principles of Biokinetics/Biodynamics 3
PTX 7300:Cellular Pharm&Tox 3
PTX 7120:Seminar/Journal Club 3
PHA 9120:Library Research Project, part 1 3
PHA 9220:Library Research Project, part 2 3
Electives (6xx level or higher) 9
   
Total Credits 30-31

 

Faculty: 

Norma C. Adragna (chair), regulation of endothelial cell ion transport

James N. McDougal, dermal toxicology, pharmacokinetic modeling

David R. Cool, neuroendocrinology, intracellular protein sorting

John M. Frazier, predictive toxicokinetics

James B. Lucot (program director), neuro/behavioral pharmacology, stress-toxicity interactions

Thomas D. Lockwood, regulation of cellular proteolysis, control of cardiac blood flow

Javier E. Stern, neurophysiology/neuroanatomy, peptidergic regulation of ion channels

Yanfang Chen, Ccrdiovascular diseases — hypertension and stroke, molecular physiology

Khalid Elased, mechanisms of disease—hypertension and diabetes

Courtney E. W. Sulentic, cellular and molecular immunotoxicology

Terry L. Oroszi – Graduate Program Director

Facilities: 

The Department of Pharmacology and Toxicology occupies the second floor of the Health Sciences Building on the main campus of Wright State University. Resources include seven well-equipped biomedical research laboratories and common equipment facilities. Wright-Patterson Air Force Base (WPAFB) is located immediately adjacent to Wright State University, where the facilities of the Air Force and Naval Toxicology laboratories are available to students in the program. In addition to providing a training site for thesis research, these sites also serve as a window to potential career opportunities for graduates of this program. The laboratories at WPAFB conduct research on the health effects of a wide variety of agents for military and other government agencies including the National Institute of Occupational Safety and Health (NIOSH), the U.S. Environmental Protection Agency (USEPA), and the Agency for Toxic Substances and Disease Registry (ATSDR). The university has an agreement of cooperation with WPAFB promoting educational and research interactions applicable to this M.S. program.

Molecular Biology and Imaging Research Facilities

Students will have the opportunity to utilize state-of-the-art equipment in this core facility maintained within the Department of Pharmacology and Toxicology. The core facility contains a sophisticated protein SELDI-TOF mass spectrometer, a laser scanning confocal microscope (Leica SP-2), an epifluorescence microscope (Leica DM-5), a phosphorimager (Fuji FLA-2000), and a multi-functional microplate reader (Packard Fusion). Computer workstations for storage, quantification, and analysis of data, and high-resolution printers for making images are available.

Integrative Pharmacology Facility

Students will also have the opportunity to utilize computerized behavioral and cardiovascular monitoring equipment to monitor the effects of stress, drugs, and toxicants on these physiological parameters in mice.