Biochemical and Molecular Biology
The Department of Biochemistry and Molecular Biology offers a program of study leading to the Master of Science degree in biochemistry and molecular biology. The M.S. program provides the student with a strong biochemical background that can serve as a basis for further graduate or professional study. Graduate study with faculty in the Department of Biochemistry and Molecular Biology leading to a Doctor of Philosophy degree is available through the Biomedical Sciences Ph.D. Program.
Major research interests of the department are grouped into three interrelated areas: molecular structure and function, molecular genetics, and the application of microarrays and magnetic resonance (MR) to biomedical research. Specific research projects deal with the structure and function of membranes, proteins and enzymes, nucleic acids, chromatin structure and function, molecular genetics, nucleotide metabolism, microbial systems biology, and the use of MR to study biochemical phenomena.
Applicants must fulfill the requirements for admission established by the Graduate School. A bachelor’s degree in the biochemical, biological, or chemical sciences, including course work in organic chemistry, physics, and calculus, is generally required. In addition, letters of recommendation are an important admission consideration.
Qualification for the Master of Science degree requires a candidate to fulfill the requirements of the Graduate School, to complete departmental course work, and to submit an acceptable research thesis.
|Dept Core and Electives||Hours|
|BMB 7500 Molecular Biochemistry I||3|
|BMB 7520 Molecular Biochemistry II||3|
|BMB 7020 Research Perspectives||3|
|BMB 7030 Research Ethics||0.5|
|II. Advanced Courses|
|Graduate Seminars in Biochemistry (BMB 8000 or BMB 9000) or other depts.||5|
|Two additional 7000 level courses||5|
|BMB 8990 Biochemistry Research (or BMB 6990 Special Problems in Biochemistry). Hands-on thesis research. Research thesis.||14|
Steven J. Berberich (Associate Provost), Regulation of the p53 tumor suppressor in cancer
Julian G. Cambronero, Signal transduction in blood cells, normal and leukemic
Madhavi P. Kadakia (Graduate Program Director), Characterization of p63 and p73 responsive gene expression using DNA microarray
Michael Leffak (Interim Chair), DNA sequences and protein at eukaryotic replication origins
Daniel T. Organisciak, Retinal light damage, cell death, and antioxidants
Lawrence J. Prochaska, Energy-transducing membranes, cytochrome C oxidase
Nicholas V. Reo, Carbohydrate metabolism, NMR, peroxisome proliferators
John V. Paietta, Gene regulation in Neurospora
Oleg Paliy, Microbial physiology and genetics, systems biology, transcriptomics and proteomics, genetic network, engineering
Heather A. Hostetler, Nuclear receptor regulation and energy homeostasis
Weiwen Long, Signaling and cancer progression
Yong-Jie Xu, Molecular mechanism of the DNA replication checkpoint
Research Assistant Professors
Michael P. Markey, Molecular genetics of tumor suppressors, genomic-based approaches for identifying transcriptional targets of RB and p53
S. Dean Rider, Jr., Chromatin remodeling enzymes and regulation of gene expression in eukaryotes
Adjunct and Joint Faculty
Patrick B. Dennis (Assistant Professor, Wright Patterson Air Force Base, WPAFB), Development of biological sensors using novel proteins
Rajesh R. Naik (Professor, WPAFB), Interfacing biomaterials with (nano)materials for addressing aerospace applications
Paul G. Seybold (Professor of Chemistry), Chemical carcinogens, physical biochemistry
BMB General Facilities
The BMB department has modern biochemical and molecular biological research equipment, including visible-ultraviolet recording spectrophotometers, spectrofluorometers, DNA synthesizer, circular dichroism spectrophotometer, FPLC, Silicon Graphics molecular modeling system, DNA array, real-time PCR system, stopped-flow reaction analyzer, liquid scintillation counters, gamma counters, ultracentrifuges, various kinds of electrophoresis equipment, phosphorimager, gas-liquid chromatographs, high pressure liquid chromatographs, and tissue culture facilities. NMR, mass spectrometry, and biocontainment facilities are available for departmental use. A modern, well-equipped laboratory animal facility is also available.
Center for Genomics Research
The Center for Genomics Research (CGR) is a research center of excellence at Boonshoft School of Medicine. CGR's primary mission is to provide support and core facilities for Wright State research faculty engaged in basic and clinical research in the areas of gene expression, flow cytometry, and genotyping. The center strives to cultivate collaborations between basic and clinical researchers at Wright State through training of personnel, collaborative projects undertaken at CGR, and joint grant submissions involving researchers and CGR members.
Nuclear Magnetic Resonance (NMR) Laboratory
The WSU Magnetic Resonance Laboratory houses two research instruments: (1) a 8.5 Tesla Wide-Bore (89 mm clear bore) 360 MHz NMR System equipped with a Tecmag Discovery Console; and (2) a Varian INOVA 600 NMR Spectrometer.
The 360 NMR system has various Bruker commercial probes for proton, fluorine, and broadband capabilities. This system is also used for NMR studies in vivo and is equipped with several home-built probes that can accommodate mice or rats.
The Varian INOVA 600 is equipped with:
- a triple resonance inverse probe (1H/13C/X),
- a broadband observe probe with a 13C/1H decouple channel (X/13C/1H),
- an Inverse Nanoprobe for 1H MAS spectroscopy in small volumes (40 ul),
- a variable temperature unit (FTS Systems, XR401 Air-Jet Crystal Cooler, -40 °C to +100 °C), and
- a Zymark XP Robotics Sample Changer (50 sample capacity.)
Initiative for Biological Computation
The purpose of this Initiative is to advance biological computation in the College of Science and Mathematics, the Boonshoft School of Medicine and Wright State University by: a) facilitating and enriching research involving biological/biomedical computation, b) recruiting and training students in the evolving areas of biological/biomedical computation, and c) serving the College, the School, the University and the community by facilitating collaborations among researchers within Wright State University and the larger community.